Characterization and evaluation of monoclonal antibodies developed for typing influenza A and influenza B viruses.
Identifieur interne : 002343 ( Main/Exploration ); précédent : 002342; suivant : 002344Characterization and evaluation of monoclonal antibodies developed for typing influenza A and influenza B viruses.
Auteurs : H H Walls ; M W Harmon ; J J Slagle ; C. Stocksdale ; A P KendalSource :
- Journal of clinical microbiology [ 0095-1137 ] ; 1986.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps monoclonaux (immunologie), Antigènes viraux (analyse), Antigènes viraux (immunologie), Humains, Souris, Souris de lignée BALB C, Technique d'immunofluorescence, Techniques immunoenzymatiques, Tests d'hémagglutination, Virus de la grippe A (), Virus de la grippe A (immunologie), Virus influenza B (), Virus influenza B (immunologie), Études d'évaluation comme sujet.
- MESH :
- analyse : Antigènes viraux.
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Antigènes viraux, Virus de la grippe A, Virus influenza B.
- Animaux, Humains, Souris, Souris de lignée BALB C, Technique d'immunofluorescence, Techniques immunoenzymatiques, Tests d'hémagglutination, Virus de la grippe A, Virus influenza B, Études d'évaluation comme sujet.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Antibodies, Viral (immunology), Antigens, Viral (analysis), Antigens, Viral (immunology), Evaluation Studies as Topic, Fluorescent Antibody Technique, Hemagglutination Tests, Humans, Immunoenzyme Techniques, Influenza A virus (classification), Influenza A virus (immunology), Influenza B virus (classification), Influenza B virus (immunology), Mice, Mice, Inbred BALB C.
- MESH :
- chemical , analysis : Antigens, Viral.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Viral, Antigens, Viral.
- classification : Influenza A virus, Influenza B virus.
- immunology : Influenza A virus, Influenza B virus.
- Animals, Evaluation Studies as Topic, Fluorescent Antibody Technique, Hemagglutination Tests, Humans, Immunoenzyme Techniques, Mice, Mice, Inbred BALB C.
Abstract
Monoclonal antibodies that are broadly reactive with influenza A or influenza B viruses were produced as stable reagents for typing influenza viruses. Monoclonal antibodies to influenza A were specific for either matrix protein or nucleoprotein. The antibodies to influenza B were specific for nucleoprotein or hemagglutinin protein. In an enzyme immunoassay procedure, influenza A antibodies detected H1N1, H2N2, and H3N2 influenza A virus strains collected between 1934 and 1984. Each of the influenza B antibodies detected influenza B reference viruses collected between 1940 and 1984. Pools of either influenza A or influenza B monoclonal antibodies were used to detect influenza viruses reisolated from clinical specimens in tissue culture. At 48 h after inoculation, the influenza A monoclonal antibodies detected 64% of H1N1 and 94% of H3N2 influenza A specimens, and the influenza B monoclonal antibodies detected 79% of the influenza B specimens. The results of this study suggest that the monoclonal antibodies described should provide useful diagnostic reagents for workers in virology laboratories who wish to isolate and identify influenza virus but have been unable to obtain consistent supplies of animal sera specific for influenza A or B viruses.
PubMed: 3517049
Affiliations:
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Le document en format XML
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Stocksdale</name></author><author><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A P" last="Kendal">A P Kendal</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1986">1986</date><idno type="RBID">pubmed:3517049</idno><idno type="pmid">3517049</idno><idno type="wicri:Area/PubMed/Corpus">000497</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000497</idno><idno type="wicri:Area/PubMed/Curation">000497</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000497</idno><idno type="wicri:Area/PubMed/Checkpoint">000440</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000440</idno><idno type="wicri:Area/Ncbi/Merge">001074</idno><idno type="wicri:Area/Ncbi/Curation">001074</idno><idno type="wicri:Area/Ncbi/Checkpoint">001074</idno><idno type="wicri:doubleKey">0095-1137:1986:Walls H:characterization:and:evaluation</idno><idno type="wicri:Area/Main/Merge">002459</idno><idno type="wicri:Area/Main/Curation">002343</idno><idno type="wicri:Area/Main/Exploration">002343</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characterization and evaluation of monoclonal antibodies developed for typing influenza A and influenza B viruses.</title><author><name sortKey="Walls, H H" sort="Walls, H H" uniqKey="Walls H" first="H H" last="Walls">H H Walls</name></author><author><name sortKey="Harmon, M W" sort="Harmon, M W" uniqKey="Harmon M" first="M W" last="Harmon">M W Harmon</name></author><author><name sortKey="Slagle, J J" sort="Slagle, J J" uniqKey="Slagle J" first="J J" last="Slagle">J J Slagle</name></author><author><name sortKey="Stocksdale, C" sort="Stocksdale, C" uniqKey="Stocksdale C" first="C" last="Stocksdale">C. Stocksdale</name></author><author><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A P" last="Kendal">A P Kendal</name></author></analytic><series><title level="j">Journal of clinical microbiology</title><idno type="ISSN">0095-1137</idno><imprint><date when="1986" type="published">1986</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal (immunology)</term><term>Antibodies, Viral (immunology)</term><term>Antigens, Viral (analysis)</term><term>Antigens, Viral (immunology)</term><term>Evaluation Studies as Topic</term><term>Fluorescent Antibody Technique</term><term>Hemagglutination Tests</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Influenza A virus (classification)</term><term>Influenza A virus (immunology)</term><term>Influenza B virus (classification)</term><term>Influenza B virus (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps monoclonaux (immunologie)</term><term>Antigènes viraux (analyse)</term><term>Antigènes viraux (immunologie)</term><term>Humains</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Technique d'immunofluorescence</term><term>Techniques immunoenzymatiques</term><term>Tests d'hémagglutination</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (immunologie)</term><term>Virus influenza B ()</term><term>Virus influenza B (immunologie)</term><term>Études d'évaluation comme sujet</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term><term>Antigens, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes viraux</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term><term>Influenza B virus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term><term>Antigènes viraux</term><term>Virus de la grippe A</term><term>Virus influenza B</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>Influenza B virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Evaluation Studies as Topic</term><term>Fluorescent Antibody Technique</term><term>Hemagglutination Tests</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Technique d'immunofluorescence</term><term>Techniques immunoenzymatiques</term><term>Tests d'hémagglutination</term><term>Virus de la grippe A</term><term>Virus influenza B</term><term>Études d'évaluation comme sujet</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Monoclonal antibodies that are broadly reactive with influenza A or influenza B viruses were produced as stable reagents for typing influenza viruses. Monoclonal antibodies to influenza A were specific for either matrix protein or nucleoprotein. The antibodies to influenza B were specific for nucleoprotein or hemagglutinin protein. In an enzyme immunoassay procedure, influenza A antibodies detected H1N1, H2N2, and H3N2 influenza A virus strains collected between 1934 and 1984. Each of the influenza B antibodies detected influenza B reference viruses collected between 1940 and 1984. Pools of either influenza A or influenza B monoclonal antibodies were used to detect influenza viruses reisolated from clinical specimens in tissue culture. At 48 h after inoculation, the influenza A monoclonal antibodies detected 64% of H1N1 and 94% of H3N2 influenza A specimens, and the influenza B monoclonal antibodies detected 79% of the influenza B specimens. The results of this study suggest that the monoclonal antibodies described should provide useful diagnostic reagents for workers in virology laboratories who wish to isolate and identify influenza virus but have been unable to obtain consistent supplies of animal sera specific for influenza A or B viruses.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Harmon, M W" sort="Harmon, M W" uniqKey="Harmon M" first="M W" last="Harmon">M W Harmon</name><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A P" last="Kendal">A P Kendal</name><name sortKey="Slagle, J J" sort="Slagle, J J" uniqKey="Slagle J" first="J J" last="Slagle">J J Slagle</name><name sortKey="Stocksdale, C" sort="Stocksdale, C" uniqKey="Stocksdale C" first="C" last="Stocksdale">C. Stocksdale</name><name sortKey="Walls, H H" sort="Walls, H H" uniqKey="Walls H" first="H H" last="Walls">H H Walls</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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